K. Altered DNA ligase III activity in the CHO EM9 mutant. [Google Scholar] Tavana H. Kelly, and A. 7. . com. Intra- and inter-rater reliability of an 11-test package for assessing dysfunction due to back or neck pain. Intra- and inter-rater reliability of an 11-test package for assessing dysfunction due to back or neck pain. Intermolecular recombination between DNAs introduced into mouse L. Phone | Current Address | Public Records | Criminal Records. [PMC free article] [Google Scholar] Cassuto E, Lightfoot LA, Howard-Flanders P. This book is the first comprehensive, authoritative reference that provides a broad and comprehensive overview of Enhanced Recovery. Research Associate, NBER. S. Identification of homologous pairing and strand-exchange activity from a human tumor cell line based on Z-DNA affinity chromatography. Intra-examiner reliability in the study selection process was assessed through the Cohen k-test assuming a threshold value of 0. Functional Ecology 34: 2270-2282. T Ljungquist 1 , B Fransson, K Harms-Ringdahl, A Björnham, A Nygren. Last updated November 18, 2023. Eight years ago, we wrote an editorial for the British Journal of Anaesthesia exploring whether rapid, uncomplicated recovery after surgery would have downstream benefits other than just reduction in hospital length of stay (LOS). solution given nonlinear model. Regulation of bacteriophage P2 late-gene expression: the ogr gene. Maessen J, Dejong CH, Hausel J, Nygren J, Lassen K, Andersen J, Kessels AG, Revhaug A, Kehlet H, Ljungqvist O, et al. 95, 6. Marimuthu K, Varadhan KK, Ljungquist O, Lobo DN Ann Surg. Going to reach for Round 4? Lynggaard vs. Ljungquist, Kent. Nygren J, Thorell A, Karpe F, Efendic S, Nair K, Ljungqvist O. Urman. 1994 Oct 14; 266 (5183):288–291. ; Gale, Robert L. & Nilsson B. G. 14 Krohn K, Ljungqvist A, Robertson B. A numeric rating scale (NRS) scores pain from 0 to 10. View Full Report. 006 Corpus ID: 238580752; Guided Aspiration for Determining the Microbiological Aetiology of Aortic Vascular Graft and Endograft Infections. Francis, Richard D. Objective: The aim of this study was to describe and present the outcomes of a specific treatment protocol for aortic vascular graft and endograft infections (VGEIs) without explantation of the infected graft. H Thompson. Occupational health physicians have better work conditions for handling. Dahlback K, Ljungquist A, Lofberg H, Dahlbäck B, Engvall E, Sakai LY. have no conflicts of interest to declare. [PMC free article] [Google Scholar] Kovar H, Wintersberger E. R. View Ljungquist vs. ; Ljungquist, Kent P. The opioid epidemic affects large parts of the world, causing an estimated 350 000 deaths annually worldwide. Nucleic Acids Res. Objective: The purpose of this study was to correlate objective measurements of muscle fatigue in the lower back to the subject's own assessment of fatigue. After addition of K media (1 mL/100 mg of muscle Ww), muscle fibers were homogenized by 4–6 strokes in the Elvhjem-Potter teflon/glass homogeniser. Tapology members can make predictions for upcoming MMA & Boxing fights. J Invest. Alexander Ljungqvist. 2017; 27:516–523. Definition of Ljungquist in the Definitions. R. Enhanced recovery after surgery (ERAS) is a protocolized scientific pathway applied to boost the outcome and enhance the recovery phase after surgery. Amyloid histochemistry. Sacrocolpopexy using autologous rectus fascia is a safe and effective alternative to synthetic mesh. and Wilson in 1952. Nat. Bergman, O. New York, NY 10012-1126. , and Axehill D. Ljungquist’s (2007) model outlines insightfully how resources, capabilities, competencies, and core competence are all linked together. 1627 Fort St Suite 300 Victoria, BC V8R 1H8. F. AU - Fearon, K. Genetic strategies have been used for more than two decades to improve bacterial bioprocesses and to simplify recovery procedures. , “ Improved path planning by tightly combining lattice-based path planning and optimal control,” IEEE Trans. CrossRef PubMed Google Scholar Ozalay M, Ozkoc G, Akpinar S, Hersekli MA, Tandogan RN. The cellulose production industry utilizes large amounts and a wide variety of chemicals, operates various chemical processes and discharges large volumes of. Danish Fight Night is closed for new predictions. se; PMID: 10444762 DOI: 10. Ten critically ill patie. Author information. K C H Fearon 1 , O Ljungqvist, M Von Meyenfeldt, A Revhaug, C H C Dejong, K Lassen, J Nygren, J Hausel, M Soop, J Andersen, H Kehlet Affiliation 1 Clinical and Surgical. All-aqueous emulsions exploit spontaneous liquid–liquid separation and due to their water-based nature are particular advantageous for the biocompatible storage and processing of biomacromolecules. This review provides an up-to-date overview about basic principles of enhanced recovery after surgery protocols, their transfer into cardiac surgery, and their current state of evidence to offer clinical implications for further adaptations and implementations of such protocols in cardiac surgery. K W Caldecott 1 , C K McKeown, J D Tucker, S Ljungquist, L H Thompson. et al. Dr. ; Ljungquist, Kent P. Considering the importance of extracellular matrix elements in tissue repair, a morphological and quantitative analysis of the elastic system components (fibrillin-1 and elastin) was performed in normal skin, normal scars, hypertrophic scars, and keloids. Department of Biotechnology, Kungliga Tekniska Högskolan, SE-100 44 Stockholm, SwedenSearch for more papers by this authorMicroscopy Research and Technique (MRT) is an international, advanced microscopy journal covering the fields of biological, clinical, chemical, & materials sciences. View in Scopus Google Scholar. K C H Fearon 1 , O Ljungqvist, M Von Meyenfeldt, A Revhaug, C H C Dejong, K Lassen, J Nygren, J Hausel, M Soop, J Andersen, H Kehlet Affiliation 1 Clinical and Surgical Sciences (Surgery), School of Clinical Sciences and Community Health, The University of Edinburgh, Royal Infirmary, 51 Little France Crescent, Edinburgh EH16 4SA, UK. J Am Acad Orthop Surg. ESPEN guideline: Clinical nutrition in surgery Arved Weimann a, *, Marco Braga b, Franco Carli c, Takashi Higashiguchi d, Martin Hübner e, Stanislaw Klek f, Alessandro Laviano g, Olle Ljungqvist h, Dileep N. [Epub ahead of print]INTRODUCTION. Open School BC helps teachers. These authors contributed equally: Ketan Mehta, Bengt Ljungquist. Ramesh, Raghu Rau, Eric So, Phillip Stocken, Kelsey Wei, William Wilhelm, and seminar participants at LBS, UNSW, SSE, NTU, and Aalto for helpful comments. Kenne K, Ljungquist S. 1988 Jun 15; 174 (3):465–470. Also known as K Settanni. Tapology members can make predictions for upcoming MMA & Boxing fights. Kem Ljungquist Larsen: sex: male age: 33: nationality: Denmark stance: southpaw: height: 6′ 6½″ / 200cm: residence: Copenhagen, Denmark: birth place: Nykobing, Denmark Given Name: Kem Ljungquist Larsen; Pro Boxing Record: 16-0-0 (Win-Loss-Draw) Nickname: N/A Current Streak: N/A; Age: 1990-07-17 | Date of Birth: 1990. 1988 Jan; 85 (1). Lips, Roger; Glick, Wendell; Gollin, Rita K. B. Langton. Bacteriophage P2, scientific name Escherichia virus P2, is a temperate phage that infects E. Comparison of the analgesic efficacy of ultrasound-guided rectus sheath block and local anesthetic infiltration for laparoscopic percutaneous extraperitoneal closure in children. Eur J Radiol (2010) C. Ljungquist's office is located at 3500 N Interstate Ave, Portland, OR. A new endonuclease from Escherichia coli acting at apurinic sites in DNA. [PMC free article] [Google Scholar] Christie GE, Haggård-Ljungquist E, Feiwell R, Calendar R. The 40-kb genome of ϕRSY1 showed high sequence similarity to the Ralstonia phage ϕRSA1 and the GMI1000 prophage ϕRSX. Avoidance of any nutritional therapy bears the risk of underfeeding during the postoperative course after major surgery. It covers the patient journey through such a program, commencing. ) “My Premature Burial” — November 19-20, 1887 — Evening Chronicle (Newcastle upon Tyne, Tyne and Wear, England) (printed under the general heading of “Tales of the Mysterious” and acknowledged as “by Edgar Allan Poe”) “My. Conflicts were resolved by discussion of each article, until consensus was reached. 148 Occurrence Handle 1:STN:280:Bi6B3MfmtlY%3DStruhl K. Ultrasound examination of peripheral nerves in the forearm. 2016. Bailter Space (a. 2007 Feb; 94(2):224-31. Homologous recombination of polyoma virus DNA in mouse cells. Clin Nutr 1999;18(2):117-20. J Trauma Acute Care Surg. Societies, Medical. J. 48 mL kg-1 min-1 (95% CI: 2. 0, = 318) for participants in the CARE group compared with no exercise group. The fusion protein was. The average duration ± SD of surgery was 5. Connective TissueMicrofibrils ISOLATION AND CHARACTERIZATION OF THREE LARGE PEPSIN-RESISTANT DOMAINSOF. To overcome the deficiency of the “first planning then tracking” motion control framework, a novel simultaneous planning and control (SPC) method is developed. In 1955, he was appointed executive officer of the Life Guards Squadron (K 1). Donald; Stauffer, Donald B. They have also lived in Winston Salem, NC and Royston, GA. net dictionary. @article{Ljungquist2021GuidedAF, title={Guided Aspiration for Determining the Microbiological Aetiology of Aortic Vascular Graft and Endograft Infections. As part of his military duties, Ljungquist organized the equestrian competition at the 1956 Stockholm Olympic Games. Affiliations 1 Department of Family Medicine, Michael G DeGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada. Intra- and inter-rater reliability of an 11-test package for assessing dysfunction due to back or neck pain. View the map. February 01 2013;37(2):259- 284. * We thank Dan Bernhardt, Logan Emery, Ilan Guttman, Paul Healy, Charles Hsu, K. A monopolar radiofrequency device can be used in facial tightening. Corresponding Author. ejvs. Infusions of carbohydrates before surgery have been shown to reduce postoperative insulin resistance. 2018; 100 (1):61–68. Sigterman, 1 KimJ. 16-0. Eric is related to Jennifer L Ljungquist and Beverly Ann Ljungquist as well as 2 additional people. We show that U. Mariah K Tanious 1 , Olle Ljungqvist, Richard D Urman Affiliation 1 *Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Boston, Massachusetts †Faculty of Medicine and Health, Department of Surgery, School of Health and Medical Sciences, Örebro University, Örebro, Sweden ‡Center for Perioperative. 5435/00124635-200903000-00006. 1987 Nov; 184 (3):229–236. Frontiers in Metabolism. g. Glick, Wendell; Crowley, J. Huber. Ljungquist T, Harms Ringdahl K, Nygren A, Jensen I. In patients with GC, malnutrition is caused by a decrease in food intake due to mechanical obstruction and cachexia, which occur during cancer progression. K. Fight Predictions. Introduction. Background: Application of evidence-based perioperative care protocols reduces complication rates, accelerates recovery and shortens hospital stay. One study found a clinically important benefit with carbohydrate drinks for postoperative anxiety compared to fasting (1 study, n=50, moderate quality of evidence). RecA-like activity in mammalian cell extracts of different origin. The course of the nerve and its intimate relationship to the humerus place it at high risk for injury with humerus fractures. Ljungquist vs. Radial nerve; humeral shaft fractures. Margaret Ljungquist was buried at Calverton National CemeterySection 24 Site 2625 210 Princeton Boulevard - Rt 25, in Calverton. Br J Surg, (12):1497-1504 2003. To evaluate the influence of abutment disconnections and reconnections on peri-implant marginal bone loss. Ends in a Draw, Majority 4 Rounds, 12:00 Total. B. Enhanced Recovery After Surgery (ERAS) is a multimodal and multiprofessional approach for minimizing surgical stress through evidence-based measures, opioid-sparing analgesia, minimally invasive surgery, effective treatment of nausea, early feeding and mobilization, and minimal use or early removal of catheters,. } and Ljungqvist, {Fredrik C. Patricia has reached the age of sixty-four years. Download full-text PDF Read full-text. Ljungquist vs. PRI 4. Chronic sun exposure results in photoaged skin with deep coarse wrinkles and loss of elasticity. Among patients with SAE during monitoring, the median duration of vital sign abnormalities was 272 min (IQR 110–447), compared to 259 min (IQR 153–394) in patients with SAE after monitoring and 261 min (IQR 132–468) in the. "Shaping Liquidity: On the Causal Effects of Voluntary Disclosure," Journal of Finance, American Finance Association, vol. Method: Twenty-one patients were tested simultaneously and independently by two physiotherapists to determine inter-rater. Infection typically follows trauma, although the inciting insult may be as minor as a scrape or an insect bite. TLDR. 2018. 2021. Slotte C. This book is the first comprehensive, authoritative reference that provides a broad and comprehensive overview of Enhanced Recovery After Surgery (ERAS). doi: 10. , N. We provide plausibly identified evidence for the role of investor disagreement in asset pricing. 246. 2019. Sports Medicine / methods*. ljungqvist "at" hhs. Website. Enhanced recovery programmes (ERPs), also known as enhanced recovery after surgery (ERAS) or fast-track surgery programmes, describe a multimodal approach to the patient's treatment pathway, with. Enhanced Recovery After Surgery (ERAS) is an evidence-based multimodal perioperative protocol focused on stress reduction and the promotion of a return to function []. Therese Ljungquist [email protected] Department of Surgical Sciences, Section for Rehabilitation Medicine, Karolinska Institutet, Sweden. Background: Women infected with human immunodeficiency virus (HIV) increasingly demonstrate abnormalities in fat distribution and metabolism; however, the effects of a home-based exercise regimen in this group have not been investigated. M. Todd Lindner. [Google Scholar]Fredriksson K, Hammarqvist F, Strigård K, Hultenby K, Ljungqvist O, Wernerman J, Rooyackers O. Results: Surgical patients may present with varying degrees of malnutrition, sarcopenia, cachexia, obesity and myosteatosis. Text-04 — “ [Romance]” — February 25 and March 4, 1843 — Saturday Museum — (Mabbott text D) (Poe sent two copies of this article to J. Epub 2023 Mar 13. 2. It fundamentally. Garaj; Holger Wiemann Bormann vs. 42 total members made predictions on this event, breaking down as follows below. 6%) or ventricular premature depolarisations (VPD; prevalence 2. provided critical input at all stages and critically revised the manuscript. 43 Corpus ID: 37947807; Osteoporosis in the aged: radiographic survey with clinical and biochemical correlations. A new temperature reconstruction with decadal resolution, covering the last two millennia, is presented for the extratropical Northern Hemisphere (90–30°N), utilizing many palaeo-temperature proxy re. also thanks G. Sugimoto K, Senda-Murata K, Oka S. 1. Jacob Bank. He received his medical degree from McGaw Medical Center of Northwestern. K. was supported by research fellowships from the Nottingham Digestive Diseases Centre National Institute for Health Research Biomedical Research Unit, and the Enhanced Recovery After Surgery Society. ; Bornstein, George; McDougal, Stuart. Design: Muscle fatigue in the lower back was assessed in healthy subjects using electromyography (EMG), endurance time and the Borg scale. A DNA-recombinogenic activity in human cells. Annals of Thoracic Surgery 163 , 356 – 361 . Fearon K, Ljungqvist O, Enhanced Recovery After Surgery Society. Ljungquist et al. A remarkable man who at-taineompic-level excellence in not. Mol Cell Biol. 7%) being the most frequent encountered anomalies (Sofi et al. 35, Issue of December is, PP. A. Consistent with models of investor disagreement,. 2. Affiliation 1 Department of Surgical Sciences, Karolinska Institutet, Sweden. Methods: 1217 units from 325 hospitals in 25 countries. and K. Expression of a DNA-ligase-stimulatory factor in Bloom's syndrome cell line GM1492. 2 million new cases a year, the majority of which undergo surgery [ 4 ]. uk. 2 HISTORY. Our natural experiment exploits the staggered implementation of EDGAR, which induces a reduction in investor disagreement. title; issue date; submit date; ascending; descending; 5; 10; American Literary Scholarship: An Annual 1978 Wijk L, Franzen K, Ljungqvist O, et al. The distribution of the air leakage places and thermal bridges in Finnish detached houses and apartment buildings. 2023. Annals of Thoracic Surgery 163 , 356 – 361 . Donald; Stauffer, Donald B. Ljungquist S. We would like to show you a description here but the site won’t allow us. axehill}@liu. Ljungquist, Kent. Authors’ 2015 additions to the IOC consensus statement: Relative Energy Deficiency in Sport (RED-S)Perioperative nutrition: Recommendations from the ESPEN expert group. Ekman K. The Society and others have now successfully implemented the ERAS protocol with improved. Our natural experiment exploits the staggered implementation of the Electronic Data Gathering, Analysis, and Retrieval (EDGAR) system, which induces a reduction in investor disagreement. 195n24. We model an IPO company's optimal response to the presence of sentiment investors and short sale constraints. 1001/jamasurg. S Ljungquist, K Kenne, L Olsson, M Sandstrom. Necrotizing soft tissue infection of the extremity is a rare but life-threatening disease. 9, 642–646 (1991). 102664 Abstract The human gene that encodes XRCC1 was cloned nearly thirty years ago but experimental analysis of this fascinating protein is still unveiling new insights into the DNA damage response. Thomsen P. Robert S. Dr. Jennings (2011) The option market's anticipation of information content in earnings announcementsPostoperative pain delays mobilization and oral intake after surgery, as well as increasing the risk of chronic pain after surgery [ 2, 3 ]. T Ljungquist, K Harms-Ringdahl, Å Nygren, I Jensen Intra- and inter-rater reliability of an 11-test package for assessing dysfunction due to back or neck pain Physiother Res Int , 4 ( 1999 ) , pp. 12423 Abstract Objective. 1999; 4:214-232 [Google Scholar] 30. J Hand Sur Am (2015) N. Affiliation 1 Department of Surgical Sciences, Karolinska Institutet, Sweden. 0 with an atypically narrow pH tolerance. [Google Scholar] Breimer LH, Lindahl T. 1988 Jun 15; 174 (3):465–470. Ljungquist vs. Nucleic Acids Res. It can be the result of a minor penetrating trauma that allows direct bacterial access to the subcutaneous tissue and deep fascia, or it can also occur at the site of a nonpenetrating trauma, such as a muscle strain. 1,2 The mortality rate in the literature ranges from 6% to 76%. , Veide A. View the map. ” whom Ljungquist identifies as Joseph M. Importance Enhanced Recovery After Surgery (ERAS) is a paradigm shift in perioperative care, resulting in substantial improvements in clinical outcomes and cost. Stein. Version 5. World Journal of Surgery. AU - Fearon, K. 1007/s00268-018-4652-4. In these situations nutritional support should be initiated without delay. Alexander Ljungqvist [email protected] Stockholm School of Economics, Swedish House of Finance. It is associated with abdominal. Ian Ljungquist. 24 Years. Eur J Biochem. Background and purpose: The intra- and inter-rater reliability of 11 tests assembled by physiotherapists for clinical purposes was investigated. 2015 Apr;49 (7):421-3. The following five cDNAs were used as DNA probes in this study: human XRCC1 (X-ray repair cross-complementing gene 1) cDNA and XRCC3 cDNA were kindly obtained from Dr K. dnarep. 1994. The activity is 2–3-fold higher in this cell line compared to normal human fibroblasts. [Google Scholar] Vollberg TM, Seal G, Sirover MA. 1977 May 10; 252 (9):2808–2814. •. Cheshire, CT 06410. K. "Shaping Liquidity: On the Causal Effects of Voluntary Disclosure," Journal of Finance, American Finance Association, vol. Proc Natl Acad Sci U S A. Ljungquist was commanding officer of the Swedish Cavalry Cadet School ( Kavalleriets kadettskola, KavKS) from 1950 to 1954 when he was promoted to Major. Engvall E. 23 of the second round in a fight that was scheduled for ten rounds. , Ljungqvist O. Return to Sport. Wijk L, Nilsson K, Ljungqvist O. 66 total members made predictions on this event, breaking down as follows below. 2019. Mutat Res. Anderson AD , McNaught CE , MacFie J , Tring I , Barker P , Mitchell CJ. 1 At that time, the concept of Enhanced Recovery After Surgery (ERAS®) was more than 15 yr old (and had been practised under various names, such as fast-track. MethodsAbstract. Patients in the FAST group (control group) fasted for 8 h before surgery. 03. Increasing incidence of primary central nervous system lymphoma but no improvement in survival in Sweden 200-2013. Contentious material about living persons that is unsourced or poorly sourced must be removed immediately, especially if potentially libelous or harmful. K C H Fearon 1 , O Ljungqvist, M Von Meyenfeldt, A Revhaug, C H C Dejong, K Lassen, J Nygren, J Hausel, M Soop, J Andersen, H Kehlet Affiliation 1 Clinical and Surgical Sciences (Surgery), School of Clinical Sciences and Community Health, The University of Edinburgh, Royal Infirmary, 51 Little France Crescent, Edinburgh EH16 4SA, UK. Can managers influence the liquidity of their firms’ shares? We use plausibly exogenous variation in the supply of public information to show that firms actively shape their information environments by voluntarily disclosing more information than regulations mandate and that such efforts improve liquidity. Karolinska Institutet, Box 127 18, S-11294 Stockholm, SwedenSearch for more papers by. D H Catlin 1 , K D Fitch, A Ljungqvist. Version 5. Female. } and Kirdyanov, {Alexander V. Eur. XRCC1 is a molecular scaffold protein that. A Probabilistic Approach for Evaluation of Radon Concentration in the Indoor Environment. 95, 6. 1080/15360288. 2008. doi: 10. Leaderboard of the best predictions by member: Ljungquist vs. Necrotizing fasciitis is often initially misdiagnosed as a more benign soft-tissue infection. Z. Nucleic Acids Res. S. To investigate climate variability in Asia during the last millennium, the spatial and temporal evolution of summer (June–July–August; JJA) temperature in eastern and south-central Asia is reconstructed using multi-proxy records and the regularized expectation maximization (RegEM) algorithm with truncated total least squares (TTLS),. Enhanced Recovery After Surgery (ERAS) is a paradigm shift in perioperative care, resulting in substantial improvements in clinical. This person is not on ResearchGate, or hasn't claimed this research yet. 4 Department of Anesthesiology, College of Medicine and Health Sciences, University of Rwanda, Kigali, Rwanda. 2. MED: 14648727. Although English and Literature might feel like chores at times, he makes the class pretty easy to deal with considering all the discussions, grades fairly, and is a tremendous help. AU - Ljungqvist, O. Ramesh, Raghu Rau, Eric So, Phillip Stocken, Kelsey Wei, William Wilhelm, and seminar participants at LBS, UNSW, SSE, NTU, and Aalto for helpful comments. Decision, Unanimous 8 Rounds, 24:00 Total. 2016. Now showing items 1-10 of 10. Ljungquist. 68-76. com : UFC 294 Paths to Victory: How Alexander Volkanovski can avenge loss to Islam Makhachev. This paper is devoted to solving autonomous navigation for unmanned surface vessels (USVs) in unknown environments. Glick, Wendell; Crowley, J. 1111/ejh. Karen F Settanni, 54. and E. XRCC1, the human gene that fully corrects the Chinese hamster ovary DNA repair mutant EM9, encodes a protein involved in the. A unique characteristic of 46BR. MED: 14648727. Results. title; issue date; submit date; ascending; descending; 5; 10; American Literary Scholarship: An Annual 1980 Ljungquist vs. C. NBER. Enhanced Recovery After Surgery started mainly with colorectal surgery but has been shown to improve outcomes in almost all major surgical specialties, making ERAS an important example of value-based care applied to surgery. W Caldecott, C. Email: alexander. Linked article: This article is commented on by Arvind Vashisht et al. ERAS has been proven to lower both recovery time and postoperative complication rates while being cost-effective at the same time [2, 3]. S Ljungquist. and N. Clin Nutr 2016 Dec 23. 9, 642–646 (1991). Background: This review aims to present a consensus for optimal perioperative care in colonic surgery and to provide graded recommendations for items for an evidenced-based enhanced perioperative protocol. ; Budd, Louis J. Effects of asbestos fibers on cell division, cell survival and formation of thioguanine resistant mutants in Chinese hamster ovary cells. [2] Bellapianta JM, Ljungquist K, Tobin E, Uhl R. 920). DNA N-glycosidases: properties of uracil-DNA glycosidase from.